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1

Preclinical Models Used for Immunogenicity Prediction of Therapeutic Proteins

Brinks, Vera, Weinbuch, Daniel, Baker, Matthew, Dean, Yann, Stas, Philippe, Kostense, Stefan, Rup, Bonita, Jiskoot, Wim

Journal:

Pharmaceutical Research

Year:

2013

Language:

english

File:

PDF, 190 KB

english, 2013

2

Therapeutic outcomes, assessments, risk factors and mitigation efforts of immunogenicity of therapeutic protein products

Yin, Liusong, Chen, Xiaoying, Vicini, Paolo, Rup, Bonita, Hickling, Timothy P.

Journal:

Cellular Immunology

Year:

2015

Language:

english

File:

PDF, 792 KB

english, 2015

3

Immunogenicity Risk Assessment for an Engineered Human Cytokine Analogue Expressed in Different Cell Substrates

Chamberlain, Paul, Rup, Bonita

Journal:

The AAPS Journal

Year:

2020

File:

PDF, 415 KB

2020

4

Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody

Hideki Yoshikawa, Wolfgang J. Rettig, Kunio Takaoka, Edward Alderman, Bonita Rup, Vicki Rosen, John M. Wozney, Joseph M. Lane, Andrew G. Huvos, Pilar Garin-Chesa

Journal:

Year:

1994

Language:

english

File:

PDF, 723 KB

english, 1994

5

Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas

Hideki Yoshikawa, Wolfgang J. Rettig, Joseph M. Lane, Kunio Takaoka, Edward Alderman, Bonita Rup, Vicki Rosen, John H. Healey, Andrew G. Huvos, Pilar Garin-Chesa

Journal:

Year:

1994

Language:

english

File:

PDF, 687 KB

english, 1994

6

Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions

Sandeep Kumar, Satish K. Singh, Xiaoling Wang, Bonita Rup, Davinder Gill

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 698 KB

english, 2011

7

Recommendations for the validation of cell-based assays used for the detection of neutralizing antibody immune responses elicited against biological therapeutics

Shalini Gupta, Viswanath Devanarayan, Deborah Finco, George R. Gunn III, Susan Kirshner, Susan Richards, Bonita Rup, An Song, Meena Subramanyam

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2011

Language:

english

File:

PDF, 301 KB

english, 2011

8

Critical ligand binding reagent preparation/selection: When specificity depends on reagents

Bonita Rup, Denise O'Hara

Journal:

The AAPS Journal

Year:

2007

Language:

english

File:

PDF, 773 KB

english, 2007

9

Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: Implications for rational design of novel and follow-on therapeutic antibodies

Sandeep Kumar, Mark A. Mitchell, Bonita Rup, Satish K. Singh

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 328 KB

english, 2012

10

VSV replication in normal and transformed T cells, an assay for T suppressor cell activation

Bonita J. Rup, David W. Scott

Journal:

Cellular Immunology

Year:

1987

Language:

english

File:

PDF, 386 KB

english, 1987

11

Role of dextran-specific suppressor T cells in the regulation of the immune response by a reactive form of dextran

Bonita J. Rup, David W. Scott

Journal:

Cellular Immunology

Year:

1987

Language:

english

File:

PDF, 850 KB

english, 1987

12

Recommendations for the design, optimization, and qualification of cell-based assays used for the detection of neutralizing antibody responses elicited to biological therapeutics

Shalini Gupta, Stephen R. Indelicato, Vijay Jethwa, Thomas Kawabata, Marian Kelley, Anthony R. Mire-Sluis, Susan M. Richards, Bonita Rup, Elizabeth Shores, Steven J. Swanson, Eric Wakshull

Journal:

Journal of Immunological Methods

Year:

2007

Language:

english

File:

PDF, 462 KB

english, 2007

13

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products

Eugen Koren, Holly W. Smith, Elizabeth Shores, Gopi Shankar, Deborah Finco-Kent, Bonita Rup, Yu-Chen Barrett, Viswanath Devanarayan, Boris Gorovits, Shalini Gupta, Thomas Parish, Valerie Quarmby, Mich

Journal:

Journal of Immunological Methods

Year:

2008

Language:

english

File:

PDF, 327 KB

english, 2008

14

Production of large numbers of hybridomas producing monoclonal antibodies against rat IgE using mast cell-deficient w/wv and sl/sld strains of mice

Journal:

Journal of Immunological Methods

Year:

1989

Language:

english

File:

PDF, 459 KB

english, 1989

15

Helper viruses associated with avian acute leukemia viruses inhibit the cellular immune response

Bonita J. Rup, Jacalyn D. Hoelzer, Henry R. Bose Jr.

Journal:

Year:

1982

Language:

english

File:

PDF, 1.02 MB

english, 1982

16

Evaluation of Pre-existing Antibody Presence as a Risk Factor for Posttreatment Anti-drug Antibody Induction: Analysis of Human Clinical Study Data for Multiple Biotherapeutics

Li Xue, Bonita Rup

Journal:

The AAPS Journal

Year:

2013

Language:

english

File:

PDF, 162 KB

english, 2013

17

Avian reticuloendotheliosis virus: Identification of the hematopoietic target cell for transformation

Lewis, Robert B., McClure, Janela, Rup, Bonita, Niesel, David W., Garry, Robert F., Hoelzer, Jacalyn D., Nazerian, Keyvan, Bose, Henry R.

Journal:

Year:

1981

Language:

english

File:

PDF, 3.00 MB

english, 1981

18

Identification of a Mouse Anti-Rat IgE Monoclonal Antibody, 44.7b, Which Inhibits IgE Binding to RBL Cells

Rup, Bonita J., Kahn, Larry E.

Journal:

International Archives of Allergy and Immunology

Year:

1989

Language:

english

File:

PDF, 1.24 MB

english, 1989

19

Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story

Rup, Bonita, Alon, Sari, Amit-Cohen, Bat-Chen, Brill Almon, Einat, Chertkoff, Raul, Tekoah, Yoram, Rudd, Pauline M., Schiffmann, Raphael

Journal:

Year:

2017

Language:

english

File:

PDF, 2.57 MB

english, 2017